Journal article
Native desorption electrospray ionization liberates soluble and membrane protein complexes from surfaces
- Abstract:
-
Mass spectrometry (MS) applications for intact protein complexes typically require electrospray (ES) ionization and have not been achieved via direct desorption from surfaces. Desorption ES ionization (DESI) MS has however transformed the study of tissue surfaces through release and characterisation of small molecules. Motivated by the desire to screen for ligand binding to intact protein complexes we report the development of a native DESI platform. By establishing conditions that preserve n...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
Robinson, C
Grant:
Investigator Award (104633/Z/14/Z)
+ Medical Research Council
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Funding agency for:
Robinson, C
Grant:
Investigator Award (104633/Z/14/Z)
+ European Research Council
More from this funder
Funding agency for:
Robinson, C
Grant:
Investigator Award (104633/Z/14/Z)
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Angewandte Chemie International Edition Journal website
- Volume:
- 56
- Issue:
- 46
- Pages:
- 14463–14468
- Publication date:
- 2017-09-18
- Acceptance date:
- 2017-09-06
- DOI:
- EISSN:
-
1521-3773
- ISSN:
-
1433-7851
- Pmid:
-
28884954
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:730106
- UUID:
-
uuid:52bb3fae-7c47-484a-85bc-500e72be2ee5
- Local pid:
- pubs:730106
- Source identifiers:
-
730106
- Deposit date:
- 2017-09-22
Terms of use
- Copyright holder:
- Ambrose et al
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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