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Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

Abstract:

Background

Tumour carbonic anhydrase IX (CAIX), a hypoxia-inducible tumour-associated cell surface enzyme, is thought to acidify the tumour microenvironment by hydrating CO2 to form protons and bicarbonate, but there is no definitive evidence for this in solid tumours in vivo.

Methods

We used 1H magnetic resonance spectroscopic imaging (MRSI) of the extracellular pH probe imidazolyl succinic acid (ISUCA) to measure and spatially map extracellular pH in HCT116 tumo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41416-018-0216-5

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
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Breast Cancer Research Foundation More from this funder
Royal Society More from this funder
Worldwide Cancer Research More from this funder
Spanish Ministry of Economy and Competitiveness More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
British Journal of Cancer Journal website
Volume:
119
Issue:
5
Pages:
622-630
Publication date:
2018-09-12
Acceptance date:
2018-07-12
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Pmid:
30206370
Source identifiers:
919737
Language:
English
Keywords:
Pubs id:
pubs:919737
UUID:
uuid:52cdb37a-05f8-4a89-ac5e-70829e2c74c6
Local pid:
pubs:919737
Deposit date:
2018-10-23

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