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Journal article

Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma

Abstract:

Oxaliplatin-based chemotherapy is used to treat patients with esophageal adenocarcinoma (EAC), but no biomarkers are currently available for patient selection. We performed a prospective, clinical trial to identify potential biomarkers associated with clinical outcomes. Tumor tissue was obtained from 38 patients with resectable EAC before and after 2 cycles of oxaliplatin-fluorouracil chemotherapy. Pre-treatment mRNA expression of 280 DNA repair (DNAR) genes was tested for association with hi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-018-24232-2

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Wellcome Trust Centre for Human Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Clinical Trial Service Unit
Role:
Author
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NIHR Biomedical Research Centre Oxford, Oxford University Clinical Academic Graduate School More from this funder
NIHR University College Hospitals Biomedical Research Centre More from this funder
Cancer Research UK Experimental Cancer Medicine Centres More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Pages:
7265
Publication date:
2018-05-08
Acceptance date:
2018-02-09
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pmid:
29739952
Language:
English
Keywords:
Pubs id:
pubs:847619
UUID:
uuid:52d1b797-0d1e-4e4a-a69f-a3640907a253
Local pid:
pubs:847619
Deposit date:
2018-06-01

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