Journal article
Human Semaphorin 3 variants link melanocortin circuit development and energy balance
- Abstract:
-
Hypothalamic melanocortin neurons play a pivotal role in weight regulation. Here, we examined the contribution of Semaphorin 3 (SEMA3) signaling to the development of these circuits. In genetic studies, we found 40 rare variants in SEMA3A-G and their receptors (PLXNA1-4; NRP1-2) in 573 severely obese individuals; variants disrupted secretion and/or signaling through multiple molecular mechanisms. Rare variants in this set of genes were significantly enriched in 982 severely obese cases compar...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 11.3MB)
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- Publisher copy:
- 10.1016/j.cell.2018.12.009
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Journal website
- Volume:
- 176
- Issue:
- 4
- Pages:
- 729-742.e18
- Publication date:
- 2019-02-07
- Acceptance date:
- 2019-12-05
- DOI:
- EISSN:
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1097-4172
- ISSN:
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0092-8674
- Pmid:
-
30661757
- Source identifiers:
-
966015
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:966015
- UUID:
-
uuid:52d5467e-ffbc-4e05-88b7-ad8cf060fd42
- Local pid:
- pubs:966015
- Deposit date:
- 2019-03-11
Terms of use
- Copyright holder:
- Van der Klaauw et al
- Copyright date:
- 2019
- Notes:
- © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license
- Licence:
- CC Attribution (CC BY)
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