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Journal article

Human Semaphorin 3 variants link melanocortin circuit development and energy balance

Abstract:

Hypothalamic melanocortin neurons play a pivotal role in weight regulation. Here, we examined the contribution of Semaphorin 3 (SEMA3) signaling to the development of these circuits. In genetic studies, we found 40 rare variants in SEMA3A-G and their receptors (PLXNA1-4; NRP1-2) in 573 severely obese individuals; variants disrupted secretion and/or signaling through multiple molecular mechanisms. Rare variants in this set of genes were significantly enriched in 982 severely obese cases compar...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cell.2018.12.009

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Wellcome Trust More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Cell Journal website
Volume:
176
Issue:
4
Pages:
729-742.e18
Publication date:
2019-02-07
Acceptance date:
2019-12-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Pmid:
30661757
Source identifiers:
966015
Language:
English
Keywords:
Pubs id:
pubs:966015
UUID:
uuid:52d5467e-ffbc-4e05-88b7-ad8cf060fd42
Local pid:
pubs:966015
Deposit date:
2019-03-11

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