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Interferon-induced transmembrane protein-3 rs12252-C is associated with rapid progression of acute HIV-1 infection in Chinese MSM cohort.

Abstract:

The interferon-inducible transmembrane protein-3 (IFITM3) is a protein that restricts multiple pathogenic viruses such as influenza virus. The single-nucleotide polymorphism rs12252-C, which is rare in Caucasian populations, but much more common in the Han Chinese population, has been found in much higher homozygous frequency in patients with severe acute influenza. Until now, there has been no study on the effect of this genetic variant on the clinical control of other viral infections.To in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1097/qad.0000000000000632

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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Grant:
2012ZX10001006-001-008,2013ZX10001004-001-002,2012ZX10001003,2012ZX10001006,
2012ZX10004904-002-002
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Grant:
D131100005313004,D131100005313005,D141100000314005,
D141100000314002
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Grant:
2011-2018-06, 2011-1011-02
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Publisher:
Lippincott, Williams and Wilkins Publisher's website
Journal:
AIDS Journal website
Volume:
29
Issue:
8
Pages:
889-894
Publication date:
2015-05-15
Acceptance date:
2015-02-19
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
Source identifiers:
514374

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