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Metabolic shift in the emergence of hyperinvasive pandemic meningococcal lineages

Abstract:

Hyperinvasive lineages of Neisseria meningitidis, which persist despite extensive horizontal genetic exchange, are a major cause of meningitis and septicaemia worldwide. Over the past 50 years one such lineage of meningococci, known as serogroup A, clonal complex 5 (A:cc5), has caused three successive pandemics, including epidemics in sub-Saharan Africa. Although the principal antigens that invoke effective immunity have remained unchanged, distinct A:cc5 epidemic clones have nevertheless eme...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep41126

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Oxford college:
Hertford College
Role:
Author
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Funding agency for:
Watkins, E
Grant:
268904 – DIVERSITY
More from this funder
Funding agency for:
Watkins, E
Grant:
268904 – DIVERSITY
More from this funder
Funding agency for:
Maiden, M
Grant:
087622
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
41126
Publication date:
2017-01-23
Acceptance date:
2016-12-15
DOI:
ISSN:
2045-2322
Pmid:
28112239
Source identifiers:
673488
Language:
English
Pubs id:
pubs:673488
UUID:
uuid:53033ad0-2b22-4757-af19-cb02f054361e
Local pid:
pubs:673488
Deposit date:
2018-03-09

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