Journal article
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia
- Abstract:
-
Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-cell RNA sequencing reveal marked heterogeneity of JMML hematopoietic stem/progenitor cells (HSPCs), including an aberrant Lin−CD34+CD38−CD90+CD45RA+ population. Single-cell HSPC index-sorting and clonogenic assays show that (1) all soma...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Rockefeller University Press Publisher's website
- Journal:
- Journal of Experimental Medicine Journal website
- Volume:
- 218
- Issue:
- 2
- Article number:
- e20180853
- Publication date:
- 2021-01-08
- Acceptance date:
- 2020-12-21
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1156015
- Local pid:
- pubs:1156015
- Deposit date:
- 2021-01-21
Terms of use
- Copyright holder:
- Louka et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 Louka et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
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