Journal article icon

Journal article

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia

Abstract:

Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-cell RNA sequencing reveal marked heterogeneity of JMML hematopoietic stem/progenitor cells (HSPCs), including an aberrant Lin−CD34+CD38−CD90+CD45RA+ population. Single-cell HSPC index-sorting and clonogenic assays show that (1) all soma...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1084/jem.20180853

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Oxford college:
Hertford College
Role:
Author
ORCID:
0000-0002-0543-7397
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
ORCID:
0000-0001-5289-1050
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
Expand authors...
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Experimental Medicine Journal website
Volume:
218
Issue:
2
Article number:
e20180853
Publication date:
2021-01-08
Acceptance date:
2020-12-21
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Language:
English
Keywords:
Pubs id:
1156015
Local pid:
pubs:1156015
Deposit date:
2021-01-21

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP