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The T cell IFT20 interactome reveals new players in immune synapse assembly

Abstract:

Sustained signalling at the immune synapse (IS) requires the synaptic delivery of recycling endosome-associated T cell antigen receptors (TCRs). IFT20, a component of the intraflagellar transport system, controls TCR recycling to the IS as a complex with IFT57 and IFT88. Here, we used quantitative mass spectrometry to identify additional interaction partners of IFT20 in Jurkat T cells. In addition to IFT57 and IFT88, the analysis revealed new binding partners, including IFT54 (also known as T...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1242/jcs.200006

Authors


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Role:
Author
ORCID:
0000-0003-3199-9868
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0001-6881-9176
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Lincoln College
Role:
Author
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More from this funder
Funding agency for:
Acuto, O
Grant:
WT094296MA
Publisher:
Company of Biologists Publisher's website
Journal:
Journal of Cell Science Journal website
Volume:
130
Issue:
6
Pages:
1110-1121
Publication date:
2018-03-15
Acceptance date:
2017-01-30
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
Pmid:
28154159
Source identifiers:
679544

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