Journal article icon

Journal article

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

Abstract:
Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleoside inhibited the enzyme, offering a novel approach for potential therapeutic development through the use of rationally designed nucleoside derived inhibitors.
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1039/c9ob01133a

Authors


More by this author
Role:
Author
ORCID:
0000-0002-2423-953X
More by this author
Role:
Author
ORCID:
0000-0003-3988-3392
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Oxford college:
University College
Role:
Author
ORCID:
0000-0002-8679-4627
Expand authors...
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Organic and Biomolecular Chemistry Journal website
Volume:
17
Pages:
8094-8105
Publication date:
2019-08-05
Acceptance date:
2019-06-12
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
Pmid:
31380542
Source identifiers:
1040002
Language:
English
Pubs id:
pubs:1040002
UUID:
uuid:53640059-5608-493f-93f3-da2c6b7b2cc5
Local pid:
pubs:1040002
Deposit date:
2019-08-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP