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Discrete and continuum approximations for collective cell migration in a scratch assay with cell size dynamics

Abstract:

Scratch assays are routinely used to study the collective spreading of cell populations. In general, the rate at which a population of cells spreads is driven by the combined effects of cell migration and proliferation. To examine the effects of cell migration separately from the effects of cell proliferation, scratch assays are often performed after treating the cells with a drug that inhibits proliferation. Mitomycin-C is a drug that is commonly used to suppress cell proliferation in this c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s11538-018-0398-2

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Oxford college:
St Hugh's College
Role:
Author
ORCID:
0000-0002-6304-9333
Australian Research Council More from this funder
Leverhulme Trust More from this funder
Royal Society More from this funder
Publisher:
Springer Publisher's website
Journal:
Bulletin of Mathematical Biology Journal website
Volume:
80
Issue:
4
Pages:
738–757
Publication date:
2018-01-25
Acceptance date:
2018-01-13
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
Source identifiers:
825129
Keywords:
Pubs id:
pubs:825129
UUID:
uuid:5393681a-b144-4a76-8d1b-7869ff08ab5e
Local pid:
pubs:825129
Deposit date:
2018-02-19

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