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Journal article

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Abstract:

Artemis (SNM1C/DCLRE1C) is an endonuclease that plays a key role in development of B- and T-lymphocytes and in dsDNA break repair by non-homologous end-joining (NHEJ). Artemis is phosphorylated by DNA-PKcs and acts to open DNA hairpin intermediates generated during V(D)J and class-switch recombination. Artemis deficiency leads to congenital radiosensitive severe acquired immune deficiency (RS-SCID). Artemis belongs to a superfamily of nucleases containing metallo-β-lactamase (MBL) and β-CASP ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gkab693

Authors


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Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
49
Issue:
16
Pages:
9310–9326
Place of publication:
England
Publication date:
2021-08-13
Acceptance date:
2021-08-11
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pmid:
34387696
Language:
English
Keywords:
Pubs id:
1191458
Local pid:
pubs:1191458
Deposit date:
2021-09-01

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