Journal article
Activation of PKA in cell requires higher concentration of cAMP than in vitro: implications for compartmentalization of cAMP signalling
- Abstract:
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cAMP is a ubiquitous second messenger responsible for the cellular effects of multiple hormones and neurotransmitters via activation of its main effector, protein kinase A (PKA). Multiple studies have shown that the basal concentration of cAMP in several cell types is about 1 M. This value is well above the reported concentration of cAMP required to half-maximally activate PKA, which measures in the 100-300 nM range. Several hypotheses have been suggested to explain this apparent discrepancy...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(pdf, 3.2MB)
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- Publisher copy:
- 10.1038/s41598-017-13021-y
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Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 7
- Article number:
- 14090
- Publication date:
- 2017-10-26
- Acceptance date:
- 2017-09-12
- DOI:
- ISSN:
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2045-2322
Item Description
- Pubs id:
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pubs:730408
- UUID:
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uuid:53b319f9-bdfc-488b-a5f8-aff13cc9a982
- Local pid:
- pubs:730408
- Deposit date:
- 2017-09-23
Terms of use
- Copyright holder:
- Koschinski and Zaccolo
- Copyright date:
- 2017
- Notes:
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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