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Activation of PKA in cell requires higher concentration of cAMP than in vitro: implications for compartmentalization of cAMP signalling

Abstract:

cAMP is a ubiquitous second messenger responsible for the cellular effects of multiple hormones and neurotransmitters via activation of its main effector, protein kinase A (PKA). Multiple studies have shown that the basal concentration of cAMP in several cell types is about 1 M. This value is well above the reported concentration of cAMP required to half-maximally activate PKA, which measures in the 100-300 nM range. Several hypotheses have been suggested to explain this apparent discrepancy...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-017-13021-y

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Oxford college:
Balliol College
Role:
Author
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Grant:
PG/10/75/28537
RG/12/3/29423
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Article number:
14090
Publication date:
2017-10-26
Acceptance date:
2017-09-12
DOI:
ISSN:
2045-2322
Pubs id:
pubs:730408
UUID:
uuid:53b319f9-bdfc-488b-a5f8-aff13cc9a982
Local pid:
pubs:730408
Deposit date:
2017-09-23

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