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Thesis

Molecular determinants of chromatin accessibility at CpG islands in mouse embryonic stem cells

Abstract:

In eukaryotic cells, transcription factors and polymerases must access DNA in the context of nucleosomes and chromatin. The accessibility of DNA sequences to such trans-acting factors is an important feature of gene regulatory elements, including promoters. In vertebrates, the majority of gene promoters coincide with CpG islands (CGIs), which remain free from DNA methylation and exhibit elevated CpG densities. This hypomethylated and CpG-rich state at CGI promoters is associated n...

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Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Author

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Role:
Supervisor
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Funding agency for:
King, H
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Keywords:
Subjects:
UUID:
uuid:53ceabe6-40ba-402e-a430-7474eac30f93
Deposit date:
2017-04-24

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