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High intraluminal pressure via H2O2 upregulates arteriolar constrictions to angiotensin II by increasing the functional availability of AT1 receptors.

Abstract:

Previously, we found that high intraluminal pressure leads to production of reactive oxygen species (ROS) and also upregulates several components of the renin-angiotensin system in the wall of small arteries. We hypothesized that acute exposure of arterioles to high intraluminal pressure in vitro via increasing ROS production enhances the functional availability of type 1 angiotensin II (Ang II) receptors (AT1 receptors), resulting in sustained constrictions. In arterioles ( approximately 180...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00205.2008

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
295
Issue:
2
Pages:
H835-H841
Publication date:
2008-08-01
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
Source identifiers:
164596

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