Journal article
Peptide splicing by the proteasome.
- Abstract:
-
The proteasome is the major protease responsible for the production of antigenic peptides recognized by CD8+ cytolytic T cells (CTL). These peptides, generally 8-to-10 amino acid-long, are presented at the cell surface by major histocompatibility complex (MHC) class I molecules. Although for years, these peptides were believed to solely derive from linear fragments of proteins, this concept was challenged several years ago by the isolation of anti-tumor CTL that recognized spliced peptides, i...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Belgian National Fund for Scientific Research
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Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of Biological Chemistry Journal website
- Volume:
- 292
- Issue:
- 51
- Pages:
- 21170–21179
- Publication date:
- 2017-11-06
- Acceptance date:
- 2017-11-06
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Pmid:
-
29109146
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:809045
- UUID:
-
uuid:53f4335d-54b5-4c12-8d05-cb2abf43e023
- Local pid:
- pubs:809045
- Source identifiers:
-
809045
- Deposit date:
- 2017-12-05
Terms of use
- Copyright holder:
- American Society for Biochemistry and Molecular Biology
- Copyright date:
- 2017
- Notes:
- © 2017 by The American Society for Biochemistry and Molecular Biology, Inc. This is the published version of the article. This is also available online from American Society for Biochemistry and Molecular Biology at: https://doi.org/10.1074/jbc.r117.807560
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