Thesis icon

Thesis

Targeting BRCA2 deficiency with GSK3 inhibitors

Abstract:

BRCA1 and BRCA2 tumour suppressors are essential for homologous recombination-mediated double-strand break repair and replication fork protection. Therefore, BRCA1 and BRCA2 are essential for cell viability. Deactivating mutations in one of these genes lead to genome instability and are associated with breast and ovarian cancer. We thus performed a chemical library screen and identified glycogen synthase kinase 3 (GSK3) inhibitors as a potent tool to kill BRCA2-deficient cells.

One ...

Expand abstract

Actions


Authors


More by this author
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Department:
Oncology
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Cancer Research UK More from this funder
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
UUID:
uuid:53fb191d-7b51-4aab-9b09-def3ec49ad18
Deposit date:
2018-02-21

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP