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Thesis

Cytotoxic T-Cells in HIV-1: "The Good" and "The Bad"

Abstract:

CD8+ T-cell antigen sensitivity is critical for optimal control of persistent viral infections, including HIV-1. The devastating HIV-1 pandemic may be countered by development of a cytotoxic T lymphocyte based vaccine if qualities associated with protection can be defined at the molecular level. However, the heterogeneity of the total viral-specific CTL response confounds identification of protective correlates and T-cell sensitivity is no exception and remains controversial. To address this ...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Oxford college:
Green Templeton College
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Role:
Supervisor
Division:
MSD
Department:
NDM
Role:
Supervisor
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Funding agency for:
Glanville, J
Grant:
G0701335/1
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:5426d2c2-5a59-47da-a615-105aa2a6e9e8
Local pid:
ora:7288
Deposit date:
2013-09-11

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