Thesis
MiR-215 regulates differentiation in colorectal cancer stem cells
- Abstract:
-
Since the initial description of cancer stem cells (CSCs) as a self-renewing subpopulation of malignant cells with tumor-initiating capacity, a growing body of evidence has supported the existence of CSCs in virtually every tumor type. Our previous work in colorectal cancer has identified the transcription factor CDX1 as a key regulator of colorectal CSC differentiation. CDX1 expression is frequently lost in colorectal cancer, resulting in more aggressive, poorly differentiated tumors with...
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Funding
+ Marshall Aid Commemoration Commission; Cancer Research UK; National Institutes of Health
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Funding agency for:
Jones, M
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:5462857b-4cee-44a8-a299-63b798a67f3f
- Local pid:
- ora:9141
- Deposit date:
- 2014-10-17
Terms of use
- Copyright holder:
- Jones, M
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available in ORA.
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