Journal article
Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability
- Abstract:
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Genetic instability, provoked by exogenous mutagens, is well linked to initiation of cancer. However, even in unstressed cells, DNA undergoes a plethora of spontaneous alterations provoked by its inherent chemical instability and the intracellular milieu. Base excision repair (BER) is the major cellular pathway responsible for repair of these lesions, and as deficiency in BER activity results in DNA damage it has been proposed that it may trigger the development of sporadic cancers. Neverthel...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 4.7MB)
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- Publisher copy:
- 10.1093/nar/gkv222
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Authors
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic Acids Research Journal website
- Volume:
- 43
- Issue:
- 7
- Pages:
- 3667-3679
- Publication date:
- 2015-03-23
- Acceptance date:
- 2015-03-04
- DOI:
- EISSN:
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1362-4962
- ISSN:
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0305-1048
- Source identifiers:
-
516651
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:516651
- UUID:
-
uuid:547a714f-d5da-461c-aecd-a443edfd52e3
- Local pid:
- pubs:516651
- Deposit date:
- 2016-06-17
Terms of use
- Copyright holder:
- Enni Markkanen et al
- Copyright date:
- 2015
- Notes:
- This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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