Thesis
Characterisation of store-operated calcium entry in a vascular endothelial cell line and impact on the production of nitric oxide
- Abstract:
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Store-operated calcium entry (SOCE) is a principal mechanism for extracellular calcium entry in non-excitable cell types, and is primarily facilitated by the calcium- release activated calcium (CRAC) channel; itself comprised of the pore-forming Orai-1 and calcium-sensing Stromal interaction molecule (STIM)-1 proteins. Depletion of endoplasmic reticulum (ER) calcium stores initiates STIM-1 translocation to defined ER-plasma membrane puncta, and subsequent Orai-STIM interaction and opening...
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Authors
Contributors
+ Parekh, A
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Funding
British Heart Foundation
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Keywords:
- Subjects:
- UUID:
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uuid:548a6062-2b2f-46ce-b91a-890561b5edff
- Deposit date:
- 2015-10-21
Terms of use
- Copyright holder:
- Batchelor, H; Helen R Batchelor
- Copyright date:
- 2014
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