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The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery

Abstract:

The ongoing explosion in genomics data has long since outpaced the capacity of conventional biochemical methodology to verify the large number of hypotheses that emerge from the analysis of such data. In contrast, it is still a gold-standard for early phenotypic validation towards small-molecule drug discovery to use probe molecules (or tool compounds), notwithstanding the difficulty and cost of generating them. Rational structure-based approaches to ligand discovery have long promised the ef...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1042/EBC20170051

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Role:
Author
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Structural Genomics Consortium More from this funder
Publisher:
Portland Press Publisher's website
Journal:
Essays in Biochemistry Journal website
Volume:
61
Issue:
5
Pages:
495-503
Publication date:
2017-11-08
Acceptance date:
2017-10-09
DOI:
EISSN:
0071-1365
ISSN:
1744-1358
Source identifiers:
745713
Pubs id:
pubs:745713
UUID:
uuid:54a4189e-4ad6-4beb-8f63-d4beffb651bd
Local pid:
pubs:745713
Deposit date:
2017-11-14

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