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Effects of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: a randomised double-blind trial

Abstract:
Background Sacubitril/valsartan reduces the risk of cardiovascular mortality among patients with heart failure with reduced ejection fraction, but its effects on kidney function and cardiac biomarkers in people with moderate-to-severe chronic kidney disease are unknown. Methods UK HARP-III was a randomised double-blind trial which included 414 participants with an estimated glomerular filtration rate (GFR) 20-60 mL/min/1.73m2 who were randomly assigned to s... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/CIRCULATIONAHA.118.034818

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
National Institute for Health Research More from this funder
Medical Research Council More from this funder
Publisher:
American Heart Association Publisher's website
Journal:
Circulation Journal website
Volume:
138
Issue:
15
Pages:
1505-1514
Publication date:
2018-10-08
Acceptance date:
2018-06-22
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Source identifiers:
905648
Keywords:
Subjects:
Pubs id:
pubs:905648
UUID:
uuid:54dfd3de-2813-4b3c-870d-103d3c465841
Local pid:
pubs:905648
Deposit date:
2018-08-14

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