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The light chain IgLV3-21 defines a new poor prognostic subgroup in chronic lymphocytic leukemia: Results of a multicenter study

Abstract:

Purpose: Unmutated (UM) immunoglobulin heavy chain variable region (IgHV) status or IgHV3-21 gene usage is associated with poor prognosis in chronic lymphocytic leukemia (CLL) patients. Interestingly, IgHV3-21 is often co-expressed with light chain IgLV3-21, which is potentially able to trigger cell-autonomous BCR-mediated signaling. However, this light chain has never been characterized independently of the heavy chain IgHV3-21.

Experimental Design:

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-0697-8777
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Les Amis de l'Institut Jules Bordet More from this funder
Fonds IRIS-Recherche More from this funder
Wallonie-Bruxelles International World More from this funder
Bekales Fundation More from this funder
National Institute for Health Research More from this funder
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Publisher:
American Association for Cancer Research Publisher's website
Journal:
Clinical Cancer Research Journal website
Volume:
24
Issue:
20
Pages:
5048-5057
Publication date:
2018-10-15
Acceptance date:
2018-06-22
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
Pmid:
29945996
Source identifiers:
859770
Language:
English
Pubs id:
pubs:859770
UUID:
uuid:54f198e6-7a95-4421-afa9-3aad2b4467c8
Local pid:
pubs:859770
Deposit date:
2019-06-25

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