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Thesis

Studies towards the total synthesis of heteroclitin F and taiwanschirin A, B, C, and D

Abstract:

This thesis initially describes model studies developed towards key structural fragments of the taiwanschirin family of natural products. Through the use of these models, an original approach was conceived to enable the installation of the (Z)–enone as a single diastereoisomer. This novel sequence has been successfully applied to a wide substrate scope including esters, amides, ketones and thioesters. Furthermore, these studies led to the assembly of the 8–membered ring in high yield, and ...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Donohoe Group
Oxford college:
Magdalen College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Donohoe Group
Oxford college:
Magdalen College
Role:
Supervisor
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Willis Group
Oxford college:
Lincoln College
Role:
Examiner
Institution:
University of Manchester
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Procter Group
Role:
Examiner
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2021-01-30

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