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The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells

Abstract:

We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-res...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.isci.2021.103353

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Role:
Author
ORCID:
0000-0003-4227-2592
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Role:
Author
ORCID:
0000-0001-8610-2806
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Publisher:
Cell Press Publisher's website
Journal:
iScience Journal website
Volume:
24
Issue:
11
Article number:
103353
Publication date:
2021-11-19
Acceptance date:
2021-10-22
DOI:
ISSN:
2589-0042
Language:
English
Keywords:
Pubs id:
1206227
Local pid:
pubs:1206227
Deposit date:
2021-11-01

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