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Size heterogeneity in the 3' noncoding region of South American isolates of yellow fever virus.

Abstract:

The 3' noncoding region (3' NCR) of flaviviruses contains secondary and tertiary structures essential for virus replication. Previous studies of yellow fever virus (YFV) and dengue virus have found that modifications to the 3' NCR are sometimes associated with attenuation in vertebrate and/or mosquito hosts. The 3' NCRs of 117 isolates of South American YFV have been examined, and major deletions and/or duplications of conserved RNA structures have been identified in several wild-type isolate...

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Publication status:
Published

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Journal:
Journal of virology
Volume:
79
Issue:
6
Pages:
3807-3821
Publication date:
2005-03-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Source identifiers:
195592

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