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Thesis

Combining regulatory angiogenic gene therapy and virotherapy for the treatment of breast cancer

Abstract:

This thesis describes the design of a virotherapy strategy capable of destroying both breast cancer vasculature and tumour cells, using an oncolytic adenovirus expressing angiogenesis-regulating proteins. Five oncolytic adenoviruses were compared to identify the best virotherapy agent for breast cancer, including measurement of cytotoxicity in vitro, and replication, intra-tumoural spread and anticancer efficacy in vivo. The viruses tested were Ad-dl922-947 (targets G1-S ...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Research group:
Gene Delivery Group- Prof. Len Seymour
Oxford college:
Balliol College
Role:
Author

Contributors

Division:
MSD
Department:
Pharmacology
Role:
Supervisor
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Funding agency for:
Bazan Peregrino, M
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Funding agency for:
Bazan Peregrino, M
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Funding agency for:
Bazan Peregrino, M
Publication date:
2007
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:550c6509-a52e-4770-8bff-dae2071c3ade
Local pid:
ora:10687
Deposit date:
2015-03-20

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