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Thesis

Mathematical modelling of metabolism and acidity in cancer

Abstract:

Human cancers exhibit the common phenotype of elevated glycolytic metabolism, which causes acidification of the tissue microenvironment and may facilitate tumour invasion. In this thesis, we use mathematical models to address a series of open problems underlying the glycolytic tumour phenotype and its attendant acidity.

We first explore tissue-scale consequences of metabolically-derived acid. Incorporating more biological detail into a canonical model of acidity at the tumour-host i...

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Institution:
University of Oxford
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Research group:
Wolfson Centre for Mathematical Biology
Oxford college:
St Catherine's College
Role:
Author

Contributors

Division:
MPLS
Department:
Mathematical Institute
Role:
Supervisor
Division:
MPLS
Department:
Mathematical Institute
Role:
Supervisor
Division:
MPLS
Department:
Mathematical Institute
Role:
Supervisor
More from this funder
Funding agency for:
McGillen, J
Grant:
U54CA143970
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK

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