Conference item
CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
- Abstract:
-
BACKGROUND: Vascular injury results in loss of endothelial nitric oxide (NO), production of reactive oxygen species (ROS), and the initiation of an inflammatory response. Both NO and ROS modulate inflammation through redox-sensitive pathways. Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide synthase (eNOS) that regulates enzymatic synthesis of either nitric oxide or ROS. We hypothesized that endothelial BH4 is an important regulator of inflammation and vascular ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1161/circulationaha.107.753558
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Bibliographic Details
- Volume:
- 118
- Issue:
- 14 Suppl
- Pages:
- S71-S77
- Host title:
- Circulation
- Publication date:
- 2008-09-01
- Event location:
- United States
- DOI:
- EISSN:
-
1524-4539
- ISSN:
-
0009-7322
- Source identifiers:
-
9365
Item Description
- Keywords:
- Pubs id:
-
pubs:9365
- UUID:
-
uuid:5558002f-3fff-46c8-ae6f-8d606bf49332
- Local pid:
- pubs:9365
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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