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CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.

Abstract:

BACKGROUND: Vascular injury results in loss of endothelial nitric oxide (NO), production of reactive oxygen species (ROS), and the initiation of an inflammatory response. Both NO and ROS modulate inflammation through redox-sensitive pathways. Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide synthase (eNOS) that regulates enzymatic synthesis of either nitric oxide or ROS. We hypothesized that endothelial BH4 is an important regulator of inflammation and vascular ...

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Publication status:
Published

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Volume:
118
Issue:
14 Suppl
Pages:
S71-S77
Host title:
Circulation
Publication date:
2008-09-01
Event location:
United States
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Source identifiers:
9365

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