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Understanding antibody binding sites

Abstract:

Antibodies are soluble proteins produced by the adaptive immune system to bind and counteract invading pathogens. The binding properties of a typical human antibody are determined by the structure of its variable domain, composed of two chains – heavy and light and by the conformation of six loops located on the surface of the variable domain, known as Complementarity Determining Regions (CDRs).

In the first chapter, we describe our analysis of the conformational space occupied by f...

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Division:
MPLS
Department:
Statistics
Department:
Department of Statistics
Role:
Author

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Department:
Department of Statistics
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:5558a55e-bb47-4b29-a681-1e58771abd1d
Deposit date:
2018-05-14

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