Thesis
Understanding antibody binding sites
- Abstract:
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Antibodies are soluble proteins produced by the adaptive immune system to bind and counteract invading pathogens. The binding properties of a typical human antibody are determined by the structure of its variable domain, composed of two chains – heavy and light and by the conformation of six loops located on the surface of the variable domain, known as Complementarity Determining Regions (CDRs).
In the first chapter, we describe our analysis of the conformational space occupied by f...
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Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:5558a55e-bb47-4b29-a681-1e58771abd1d
- Deposit date:
- 2018-05-14
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