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Thesis

The evaluation of the IGF-1R as a proposed biomarker for DNA damaging cancer therapies

Abstract:

Introduction The IGF-1 receptor (IGF-1R) is overexpressed in many cancers, with roles in cell proliferation and survival. IGF-1R inhibition enhances radio- and chemo-sensitivity, potentially influencing DNA damage response, whilst IGF1R SNP rs4966013 has been identified as the SNP in the p53 stress response network most significantly associated with differences in chemosensitivity.

Aims: 1. Test whether IGF-1R protein expression correlates with IGF-1R mRNA, he...

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Institution:
University of Oxford
Research group:
Val Macaulay - IGF group
Department:
Medical Sciences Division - Radiation,Oncology and Biology
Role:
Author

Contributors

Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
Publication date:
2014
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:5567d883-e1dd-4cf8-a702-ba5533e65b01
Local pid:
ora:9781
Deposit date:
2015-01-21

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