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The influence of hydrostatic pressure on tissue engineered bone development

Abstract:

The hydrostatic pressure stimulation of an appropriately cell{seeded porous scaffold within a bioreactor is a promising method for engineering bone tissue external to the body. We propose a mathematical model, and employ a suite of candidate constitutive laws, to qualitatively describe the effect of applied hydrostatic pressure on the quantity of minerals deposited in such an experimental setup. By comparing data from numerical simulations with experimental observations under a number of stim...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jtbi.2015.12.020

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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Theoretical Biology Journal website
Volume:
394
Issue:
2016
Pages:
149-159
Publication date:
2016-01-18
Acceptance date:
2015-12-17
DOI:
ISSN:
1095-8541
Source identifiers:
580177
Keywords:
Pubs id:
pubs:580177
UUID:
uuid:557635ba-bfe7-459a-87df-74303270c65b
Local pid:
pubs:580177
Deposit date:
2015-12-18

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