HIV-1 p24Gag adaptation to modern and archaic HLA-allele frequency differences in ethnic groups contributes to viral subtype diversification
Pathogen-driven selection and past interbreeding with archaic human lineages have resulted in differences in HLA-allele frequencies between modern human populations. Whether or not this variation affects pathogen subtype diversification is unknown. Here we show a strong positive correlation between ethnic diversity in African countries and both HIV-1 p24gag and subtype diversity. We demonstrate that ethnic HLA-allele differences between populations has influenced HIV-1 subtype diversification...Expand abstract
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- Kist et al.
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- ©2020 The Author(s). Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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