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HIV-1 p24Gag adaptation to modern and archaic HLA-allele frequency differences in ethnic groups contributes to viral subtype diversification

Abstract:

Pathogen-driven selection and past interbreeding with archaic human lineages have resulted in differences in HLA-allele frequencies between modern human populations. Whether or not this variation affects pathogen subtype diversification is unknown. Here we show a strong positive correlation between ethnic diversity in African countries and both HIV-1 p24gag and subtype diversity. We demonstrate that ethnic HLA-allele differences between populations has influenced HIV-1 subtype diversification...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/ve/veaa085

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Publisher:
Oxford University Press Publisher's website
Journal:
Virus Evolution Journal website
Volume:
6
Issue:
2
Article number:
veaa085
Publication date:
2020-11-09
Acceptance date:
2020-10-20
DOI:
EISSN:
2057-1577
Language:
English
Keywords:
Pubs id:
1145397
Local pid:
pubs:1145397
Deposit date:
2020-11-13

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