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The activity of JmjC histone lysine demethylase KDM4A is highly sensitive to oxygen concentrations

Abstract:

The JmjC histone lysine demethylases (KDMs) are epigenetic regulators involved in the removal of methyl groups from post-translationally modified lysyl residues within histone tails, modulating gene transcription. These enzymes require molecular oxygen for catalytic activity and, as 2-oxoglutarate (2OG)-dependent oxygenases, are related to the cellular oxygen sensing HIF hydroxylases PHD2 and FIH. Recent studies have indicated that the activity of some KDMs, including the pseudogene-encoded K...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acschembio.6b00958

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Institution:
University of Oxford
Oxford college:
Linacre College
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Engineering and Physical Sciences Research Council More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
ACS Chemical Biology Journal website
Volume:
12
Issue:
4
Pages:
1011–1019
Publication date:
2017-01-04
Acceptance date:
2017-01-04
DOI:
EISSN:
1554-8937
ISSN:
1554-8929
Pubs id:
pubs:680460
UUID:
uuid:558fc8d9-1840-4bd8-86b1-b91d2dda5e0a
Local pid:
pubs:680460
Deposit date:
2017-02-16

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