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Assessment of Metformin Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate.

Abstract:

Metformin improves cardiovascular outcomes in type 2 diabetes, but its exact mechanisms of action remain controversial. We used hyperpolarized [1-(13)C]pyruvate magnetic resonance spectroscopy to determine the effects of metformin treatment upon heart and liver pyruvate metabolism in rats in vivo Both oral treatment for four weeks and a single intravenous metformin infusion significantly increased the cardiac [1-(13)C]lactate:[1-(13)C]pyruvate ratio, but had no effect on the [1-(13)C]bicarbon...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2337/db16-0804

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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Funding agency for:
Miller, J
Grant:
EP/M508111/1
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Funding agency for:
Tyler, D
Grant:
RG/11/9/28921
FS/14/17/30634
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Funding agency for:
Heather, L
Grant:
11/0004175
Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
65
Issue:
12
Pages:
3544-3551
Publication date:
2016-08-25
Acceptance date:
2016-08-19
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Source identifiers:
640785
Language:
English
Keywords:
Pubs id:
pubs:640785
UUID:
uuid:55cee995-e6c0-46c8-8c61-dfb03c6f540f
Local pid:
pubs:640785
Deposit date:
2016-08-31

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