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Journal article

Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma

Abstract:

The Asp358Ala variant in the interleukin-6 receptor (IL-6R) gene has been implicated in asthma, autoimmune and cardiovascular disorders, but its role in other respiratory conditions such as chronic obstructive pulmonary disease (COPD) has not been investigated. The aims of this study were to evaluate whether there is an association between Asp358Ala and COPD or asthma risk, and to explore the role of the Asp358Ala variant in sIL-6R shedding from neutrophils and its pro-inflammatory effects in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/hmg/ddx053

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Volume:
26
Issue:
8
Pages:
1584-1596
Publication date:
2017-02-17
Acceptance date:
2017-02-08
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Pmid:
28334838
Source identifiers:
871500
Language:
English
Pubs id:
pubs:871500
UUID:
uuid:55f1e7a2-fbae-4f65-8656-b1dde2950343
Local pid:
pubs:871500
Deposit date:
2018-07-25

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