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Journal article

A C-terminal amphipathic helix is necessary for the in vivo tubule-shaping function of a plant reticulon.

Abstract:

Reticulons (RTNs) are a class of endoplasmic reticulum (ER) membrane proteins that are capable of maintaining high membrane curvature, thus helping shape the ER membrane into tubules. The mechanism of action of RTNs is hypothesized to be a combination of wedging, resulting from the transmembrane topology of their conserved reticulon homology domain, and scaffolding, arising from the ability of RTNs to form low-mobility homo-oligomers within the membrane. We studied the plant RTN isoform RTN13...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1605434113

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Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of USA Journal website
Publication date:
2016-09-12
Acceptance date:
2016-08-05
DOI:
ISSN:
1091-6490
Source identifiers:
644032
Keywords:
Pubs id:
pubs:644032
UUID:
uuid:56136a4f-423c-491f-90fb-2d5f146d0f05
Local pid:
pubs:644032
Deposit date:
2016-09-16

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