A C-terminal amphipathic helix is necessary for the in vivo tubule-shaping function of a plant reticulon.
Reticulons (RTNs) are a class of endoplasmic reticulum (ER) membrane proteins that are capable of maintaining high membrane curvature, thus helping shape the ER membrane into tubules. The mechanism of action of RTNs is hypothesized to be a combination of wedging, resulting from the transmembrane topology of their conserved reticulon homology domain, and scaffolding, arising from the ability of RTNs to form low-mobility homo-oligomers within the membrane. We studied the plant RTN isoform RTN13...Expand abstract
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- Peer reviewed
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- National Academy of Sciences Publisher's website
- Proceedings of the National Academy of Sciences of USA Journal website
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- Breeze et al
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- Author(s) retain copyright; published by the National Academy of Sciences under license. The final version is available online from the National Academy of Sciences at: [10.1073/pnas.1605434113].
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