Journal article
Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression.
- Abstract:
-
Recruitment of CCR2(+)Ly6C(high) monocytes to sites of infection is essential for efficient clearance of microbial pathogens. Although CCR2-mediated signals promote monocyte emigration from bone marrow, the contribution of CCR2 to later stages of monocyte recruitment remains unresolved. In this article, we show that CCR2 deficiency markedly worsens hepatic Listeria monocytogenes infection because Ly6C(high) monocytes are retained in the bone marrow. Intravenously transferred, CCR2-deficient L...
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- Publisher copy:
- 10.4049/jimmunol.0904160
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Authors
Bibliographic Details
- Journal:
- Journal of Immunology
- Volume:
- 184
- Issue:
- 11
- Pages:
- 6266-6274
- Publication date:
- 2010-06-01
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Source identifiers:
-
426283
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:426283
- UUID:
-
uuid:56319cd2-431b-4866-b072-a4172b96ca0a
- Local pid:
- pubs:426283
- Deposit date:
- 2014-07-10
Terms of use
- Copyright date:
- 2010
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