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Thesis

E2F7: a member of the E2F family with a novel mechanism of transcriptional repression

Abstract:

The mammalian E2F family of transcription factors plays a crucial role in the regulation of cellular proliferation, apoptosis and differentiation. E2F7 and E2F8 are the most recently identified family members and have unusual features that distinguish them from other members in the E2F family, including two distinct DNA-binding domains that bind to DNA in a DP-independent manner. E2F7 and E2F8 have been shown to be transcriptional repressors. However, the mechanism by which E2F7 represses ...

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Institution:
University of Oxford
Division:
MSD
Oxford college:
Linacre College
Role:
Author
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Division:
MSD
Department:
Pharmacology
Role:
Author

Contributors

Division:
MSD
Department:
Pharmacology
Role:
Supervisor
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Funding agency for:
Kesoglidou, P
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:5694f75b-0e73-493c-a6bd-da10793aded3
Local pid:
ora:6678
Deposit date:
2013-01-28

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