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Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound.

Abstract:

BACKGROUND: Oncolytic viruses are among the most powerful and selective cancer therapeutics under development and are showing robust activity in clinical trials, particularly when administered directly into tumor nodules. However, their intravenous administration to treat metastatic disease has been stymied by unfavorable pharmacokinetics and inefficient accumulation in and penetration through tumors. METHODS: Adenovirus (Ad) was "stealthed" with a new N-(2-hydroxypropyl)methacrylamide polyme...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/jnci/djt305

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Funding agency for:
Carlisle, R
Grant:
WT088877/Z/09/Z
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Funding agency for:
Carlisle, R
Grant:
WT088877/Z/09/Z
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Funding agency for:
Choi, J
Grant:
EP/F011547/14
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Funding agency for:
Coussios, C
Grant:
EP/F011547/14
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Funding agency for:
Seymour, L
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Publisher:
Oxford University Press Publisher's website
Journal:
Journal of the National Cancer Institute Journal website
Volume:
105
Issue:
22
Pages:
1701-1710
Publication date:
2013-11-01
DOI:
EISSN:
1460-2105
ISSN:
0027-8874
Source identifiers:
436048

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