Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound.
BACKGROUND: Oncolytic viruses are among the most powerful and selective cancer therapeutics under development and are showing robust activity in clinical trials, particularly when administered directly into tumor nodules. However, their intravenous administration to treat metastatic disease has been stymied by unfavorable pharmacokinetics and inefficient accumulation in and penetration through tumors. METHODS: Adenovirus (Ad) was "stealthed" with a new N-(2-hydroxypropyl)methacrylamide polyme...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 10.7MB)
- Publisher copy:
- Local pid:
- Deposit date:
- Copyright holder:
- Carlisle et al
- Copyright date:
- Copyright © 2013 Carlisle et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact email@example.com.
If you are the owner of this record, you can report an update to it here: Report update to this record