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Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial.

Abstract:

Because treatment with third-generation cephalosporins is associated with slow clinical improvement and high relapse burden for enteric fever, whereas the fluoroquinolone gatifloxacin is associated with rapid fever clearance and low relapse burden, we postulated that gatifloxacin would be superior to the cephalosporin ceftriaxone in treating enteric fever.We did an open-label, randomised, controlled, superiority trial at two hospitals in the Kathmandu valley, Nepal. Eligible participants were...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/s1473-3099(15)00530-7

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Funding agency for:
Baker, S
Grant:
Sir Henry Dale Fellowship 100087/Z/12/Z
More from this funder
Funding agency for:
Baker, S
Grant:
Sir Henry Dale Fellowship 100087/Z/12/Z
Wellcome Trust More from this funder
Li Ka Shing Foundation Global Health Programme More from this funder
Publisher:
Lancet Publisher's website
Journal:
Lancet Infectious Diseases Journal website
Publication date:
2016-01-20
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
Source identifiers:
597885
Language:
English
Pubs id:
pubs:597885
UUID:
uuid:56ea0d6e-a11f-4a6c-8198-1748a7d34c51
Local pid:
pubs:597885
Deposit date:
2016-02-09

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