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Cytochrome P450/ABC transporter inhibition simultaneously enhances ivermectin pharmacokinetics in the mammal host and pharmacodynamics in Anopheles gambiae

Abstract:

Mass administration of endectocides, drugs that kill blood-feeding arthropods, has been proposed as a complementary strategy to reduce malaria transmission. Ivermectin is one of the leading candidates given its excellent safety profile. Here we provide proof that the effect of ivermectin can be boosted at two different levels by drugs inhibiting the cytochrome or ABC transporter in the mammal host and the target mosquitoes. Using a mini-pig model, we show that drug-mediated cytochrome P450/AB...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-017-08906-x

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Role:
Author
ORCID:
0000-0001-9812-050X
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Role:
Author
ORCID:
0000-0003-0658-9330
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Role:
Author
ORCID:
0000-0002-6401-9187
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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Issue:
1
Article number:
8535
Place of publication:
England
Publication date:
2017-08-17
Acceptance date:
2017-07-14
DOI:
EISSN:
2045-2322
Pmid:
28819225

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