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Pulling on my heartstrings: mechanotransduction in cardiac development and function

Abstract:

Endothelial cells line the surface of the cardiovascular system and display a large degree of heterogeneity due to developmental origin and location. Despite this heterogeneity, all endothelial cells are exposed to wall shear stress (WSS) imparted by the frictional force of flowing blood, which plays an important role in determining the endothelial cell phenotype. Although the effects of WSS have been greatly studied in vascular endothelial cells, less is known about the role of WSS in regula...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1097/MOH.0000000000000240

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Funding agency for:
McCormick, M
Grant:
T32 HL07954
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Funding agency for:
Tzima, E
Grant:
NIH HL117256
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Funding agency for:
Tzima, E
Grant:
NIH HL117256
Publisher:
Lippincott, Williams and Wilkins Publisher's website
Journal:
Current opinion in hematology Journal website
Volume:
23
Issue:
3
Pages:
235-242
Publication date:
2016-05-01
DOI:
EISSN:
1531-7048
ISSN:
1065-6251
Source identifiers:
609369
Language:
English
Keywords:
Pubs id:
pubs:609369
UUID:
uuid:56f11c8a-ee52-44dd-b690-cecd2572ef9d
Local pid:
pubs:609369
Deposit date:
2016-04-26

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