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Journal article

A causal role for TRESK loss of function in migraine mechanisms

Abstract:

The two-pore potassium channel, TRESK has been implicated in nociception and pain disorders. We have for the first time investigated TRESK function in human nociceptive neurons using induced pluripotent stem cell-based models. Nociceptors from migraine patients with the F139WfsX2 mutation show loss of functional TRESK at the membrane, with a corresponding significant increase in neuronal excitability. Furthermore, using CRISPR-Cas9 engineering to correct the F139WfsX2 mutation, we show a reve...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awz342

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Role:
Author
ORCID:
0000-0002-6330-2802
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John Fell Fund More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
142
Issue:
12
Pages:
3852-3867
Publication date:
2019-11-19
Acceptance date:
2019-09-16
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Pmid:
31742594
Source identifiers:
1073380
Language:
English
Keywords:
Pubs id:
pubs:1073380
UUID:
uuid:57203aa1-d7b6-4144-be2e-6fc8cba4dc53
Local pid:
pubs:1073380
Deposit date:
2019-12-17

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