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Thesis

Mechanisms of induction of type I/III interferons in cancer cells by ionizing radiation and the role of tumour cell-derived type I IFN and type I IFN signalling in anti-tumour immune response

Abstract:

Interferons (IFNs) are a group of cytokines that have been shown to play an important role in both radiotherapy and the anti-tumour immune response. How ionizing radiation (IR) induces IFNs in the tumour is still not fully understood. We found that IR directly induced dose- and time-dependent upregulation of I/III IFNs in cancer cells. This induction occurs via cytosolic DNA sensors-STING-TBK1-IRFs signalling axis and to less extent, the NF-κB pathway in colorectal cancer cells. Furt...

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Division:
MSD
Department:
Oncology
Department:
University of Oxford
Role:
Author

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Chen, J
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Funding agency for:
Chen, J
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:572d85d8-b20d-4709-8dbd-d920bedc3bbc
Deposit date:
2019-08-23

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