Antihypertensive drug class effects on inter-individual blood pressure variability and the associated risk of stroke

Thesis

Visit-to-visit variability in systolic blood pressure (SBP) predicts the subsequent risk of stroke, independent of mean SBP. It was reduced by amlodipine and increased by atenolol in the ASCOT-BPLA and MRC randomized controlled trials (RCTs), explaining the difference in risk of stroke between treatment groups that was not explained by mean SBP. Therefore, I performed a series of systematic reviews to examine the effects of all antihypertensive drugs in RCTs and how these effects relate t...

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Authors: Webb, A; Alastair J. S. Webb

• Publication date: 2011
• Type of award: MSc by Research
• Level of award: Masters
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: meta-analysis; systematic review; blood pressure variability; hypertension; stroke; antihypertensives
• Subjects: Hypertension; Cardiovascular disease; Epidemiology; Stroke; Disease prevention; Blood pressure variability