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Journal article

PrPSc binding antibodies are potent inhibitors of prion replication in cell lines

Abstract:

Conversion of the cellular α-helical prion protein (PrPC) into a disease-associated isoform (PrPSc) is central to the pathogenesis of prion diseases. Molecules targeting either normal or disease-associated isoforms may be of therapeutic interest, and the antibodies binding PrPC have been shown to inhibit prion accumulation in vitro. Here we investigate whether antibodies that additionally target disease-associated isoforms such as PrPSc inhibit prion replication in ovine PrP-inducible scrapie...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.m402270200

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Role:
Author
ORCID:
0000-0002-8175-866X
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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
279
Issue:
38
Pages:
39671-39676
Publication date:
2004-09-10
Acceptance date:
2004-05-06
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pmid:
15133046
Language:
English
Keywords:
Pubs id:
1222653
Local pid:
pubs:1222653
Deposit date:
2022-07-03

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