Thesis
The requirement for endothelial cell tetrahydrobiopterin in health and disease
- Abstract:
-
Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide synthase (eNOS) function and nitric oxide (NO) generation. Augmentation of BH4 levels can prevent eNOS uncoupling and improve endothelial dysfunction in vascular disease states. However, the physiological requirement for de-novo endothelial cell BH4 biosynthesis in eNOS function remains unclear. We generated a novel mouse model with endothelial cell-specific deletion of GCH1, encoding GTP cycl...
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Authors
Contributors
+ Channon, K
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Supervisor
Funding
+ British Heart Foundation
More from this funder
Funding agency for:
Chuaiphichai, S
Grant:
FS 10/53/28679
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:57c65ae4-b438-418f-ba25-7c44d77f0670
- Local pid:
- ora:11858
- Deposit date:
- 2015-07-10
Terms of use
- Copyright holder:
- Chuaiphichai, S
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available via ORA.
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