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Preeclampsia and uteroplacental acute atherosis: Immune and inflammatory factors

Abstract:

Acute atherosis (Aa) affects uteroplacental spiral arteries in 20-40% of cases of preeclampsia. Its hallmark is lipid-filled, CD68-positive foam cells. It usually develops in the decidua (the pregnancy endometrium) at the distal ends of arteries that are often unremodelled in their proximal segments. Aa resembles the early stages of atherosclerosis, which becomes symptomatic in the middle-aged and elderly, in contrast to the young age of pregnant women with Aa. Although the mechanisms of Aa a...

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Publisher copy:
10.1016/j.jri.2013.09.001

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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
Publisher:
Elsevier
Journal:
Journal of Reproductive Immunology
Volume:
101-102
Issue:
1
Pages:
120-126
Publication date:
2014-01-01
DOI:
EISSN:
1872-7603
ISSN:
0165-0378
Source identifiers:
462905
Language:
English
Keywords:
Pubs id:
pubs:462905
UUID:
uuid:57d49c20-05dc-4537-b25a-a34e182d80fa
Local pid:
pubs:462905
Deposit date:
2015-01-03

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