Journal article icon

Journal article

BNC1 regulates cell heterogeneity in human pluripotent stem cell-derived epicardium

Abstract:

The murine developing epicardium heterogeneously expresses the transcription factors TCF21 and WT1. Here, we show that this cell heterogeneity is conserved in human epicardium, regulated by BNC1 and associated with cell fate and function. Single cell RNA sequencing of epicardium derived from human pluripotent stem cells (hPSC-epi) revealed that distinct epicardial subpopulations are defined by high levels of expression for the transcription factors BNC1 or TCF21. WT1+ cells are included in th...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1242/dev.174441

Authors


More by this author
Role:
Author
ORCID:
0000-0001-5771-1565
More by this author
Role:
Author
ORCID:
0000-0001-5089-5875
More by this author
Role:
Author
ORCID:
0000-0002-7798-7953
More by this author
Role:
Author
ORCID:
0000-0003-4552-8266
Expand authors...
Publisher:
Company of Biologists Publisher's website
Journal:
Development Journal website
Volume:
146
Issue:
24
Article number:
dev174441
Publication date:
2019-11-25
Acceptance date:
2019-11-21
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
Pmid:
31767620
Source identifiers:
1076079
Language:
English
Keywords:
Pubs id:
pubs:1076079
UUID:
uuid:57faa466-1682-42f3-8fed-f2fb99f7e078
Local pid:
pubs:1076079
Deposit date:
2020-01-06

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP