Journal article
BNC1 regulates cell heterogeneity in human pluripotent stem cell-derived epicardium
- Abstract:
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The murine developing epicardium heterogeneously expresses the transcription factors TCF21 and WT1. Here, we show that this cell heterogeneity is conserved in human epicardium, regulated by BNC1 and associated with cell fate and function. Single cell RNA sequencing of epicardium derived from human pluripotent stem cells (hPSC-epi) revealed that distinct epicardial subpopulations are defined by high levels of expression for the transcription factors BNC1 or TCF21. WT1+ cells are included in th...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 15.3MB)
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- Publisher copy:
- 10.1242/dev.174441
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Authors
Bibliographic Details
- Publisher:
- Company of Biologists Publisher's website
- Journal:
- Development Journal website
- Volume:
- 146
- Issue:
- 24
- Article number:
- dev174441
- Publication date:
- 2019-11-25
- Acceptance date:
- 2019-11-21
- DOI:
- EISSN:
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1477-9129
- ISSN:
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0950-1991
- Pmid:
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31767620
- Source identifiers:
-
1076079
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1076079
- UUID:
-
uuid:57faa466-1682-42f3-8fed-f2fb99f7e078
- Local pid:
- pubs:1076079
- Deposit date:
- 2020-01-06
Terms of use
- Copyright holder:
- Gambardella et al
- Copyright date:
- 2019
- Notes:
- © Author(s) 2019. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/4.0. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
- Licence:
- CC Attribution (CC BY)
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